Name: Salcaprozate Sodium（SNAC）powder
Brand: Joyous Pellets Supplement raw materials, cosmetic ingredients, weight
Availability: InStock
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Salcaprozate Sodium, sodium 8-(2-hydroxybenzamido)octanoate, referred to as SNAC, is a dicarbonate phosphate compound absorption enhancer, used to treat gastrointestinal diseases, especially suitable for the absorption of dicarbonate phosphate compounds Gastrointestinal diseases caused by adverse effects. Salcaprozate Sodium is also an oral absorption enhancer and acts as a delivery agent for oral forms of heparin and insulin. Salcaprozate sodium increases passive transcellular penetration of small intestinal epithelial cells by increasing lipophilicity due to non-covalent macromolecular complexation.

Product Name

Salcaprozate Sodium

Other Name

SNAC/sodium,sodium 8-(2-hydroxybenzamido)octanoate

Specification

99%

CAS No

203787-91-1

Molecular Formula

C15H22NNaO4

Appearance

white powder

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Desciption

Product information
What is Salcaprozate Sodium powder?
Salcaprozate Sodium, sodium 8-(2-hydroxybenzamido)octanoate, referred to as SNAC, is a dicarbonate phosphate compound absorption enhancer, used to treat gastrointestinal diseases, especially suitable for the absorption of dicarbonate phosphate compounds Gastrointestinal diseases caused by adverse effects. Salcaprozate Sodium is also an oral absorption enhancer and acts as a delivery agent for oral forms of heparin and insulin. Salcaprozate sodium increases passive transcellular penetration of small intestinal epithelial cells by increasing lipophilicity due to non-covalent macromolecular complexation. SNAC is essentially a chemically synthesized fatty acid derivative. It was first selected by Emisphere as a highly effective molecule among many penetration enhancers. The improvement of gastrointestinal epithelial cell membrane permeability by SNAC may be related to membrane perturbation, membrane fluidization, solubility changes of API or tight junction opening, or it may be through non-covalent binding to API Increase its hydrophobic effect to improve cross-cell penetration. Novo Nordisk's FDA-approved oral formulation Rybelsus, which was launched in 2019 and is made of SNAC and semaglutide, is an example. Semaglutide acts as a GLP-1 The fat-soluble derivative can achieve gastric absorption under the action of the absorption enhancer N-[8-(2-hydroxybenzoyl)aminocaprylic acid sodium] (SNAC).
Joyous Salcaprozate Sodium powder specification

Terms	Standard	Terms	Standard
Product Name	Salcaprozate Sodium(SNAC)	Appearance	Off white powder
Assay	98%	Loss on Drying	≤2%
Total Heavy Metals	≤10 ppm	Ash	≤2%
As	≤0.5ppm	Total Plate Count	≤750 cfu/g
Pb	≤0.5ppm	Yeast and Mold	≤100 cfu/g
Cd	≤0.5ppm	Coliforms	Negative
Hg	≤0.1ppm	E.Coli	Negative
Packing	Pack in 25kgs paper-drums, inner by double plastic bag	Shelf life	24 months under the above condition, and in its original package

Product Introduction of Salcaprozate Sodium
Taking smeglutide as an example, SNAC can interact with the drug through non-covalent bonds, increase the lipophilicity of the drug, and promote drug absorption through the paracellular pathway. It has a stronger ability to promote penetration, promote the monomerization of semaglutide, and inhibit the formation of oligomers of GLP-1 analogues, thereby reducing the impact of the preparation itself on oral absorption. At the same time, SNAC can improve cell membrane fluidity and combine with gastric epithelium through weak intermolecular interactions to promote absorption. While promoting absorption, SNAC can locally adjust the pH value of the gastrointestinal tract by instantly neutralizing the acidic environment, inhibiting pepsin activity and reducing proteolysis. SNAC is an N-acetylated amino acid derivative of salicylic acid, which can be used as a carrier to penetrate into the gastrointestinal mucosa together with macromolecular drugs. It shows amphipathicity and weak acidity, but because the salicylamide region of SNAC has more hydrophilic functional groups distributed, the insertion efficiency of the hydrophobic region of SNAC into the phospholipid membrane is lower than that of C10. In general, more SNAC is needed to improve gastrointestinal permeability than C10.
The largest formulation application of SNAC: used as a delivery agent for oral drug preparations, promoting the monomerization of semaglutide and promoting its transcellular transport, increasing the local pH in the stomach and thereby reducing the degradation of pepsin. Applying SNAC technology, it is possible to develop formulations for oral administration of certain macromolecules with poor bioavailability such as insulin, heparin or small molecules without changing their chemical form, biological integrity or pharmacological properties.

Figure 2. Mode of action of C10. The diagram represents the proposed mechanism of action of C10 via paracellular flux (left) and transcellular perturbation (right) to induce drug permeability across the intestinal mucosa. Abbreviations: PLC: phospholipase C; PIP2: phosphatidylinositol 4,5-bisphosphate; DAG: di-acyl glycerol; PKC: protein kinase C; IP3R: inositol triphosphate receptor; MLC: myosin light chain, CAM: calmodulin; ZO: zonula occludens; JAM: junctional adhesion molecule. Image created using a template from Servier Medical Art under a Creative Commons Attribution License.
Penetration enhancers help reduce the epithelial barrier's obstruction to the absorption of peptide drugs, mainly by opening intercellular tight junctions, promoting paracellular transport of peptide drugs, or enhancing transcellular transport of drugs by means of membrane perturbation, by increasing intestinal epithelial The instantaneous permeability of cells promotes the absorption of peptide drugs.
Use medium-chain fatty acids as penetration enhancers to promote oral absorption of peptides. Sodium decanoate (C10, Sodium Caprate) promotes the permeability of the gastrointestinal tract, thereby promoting the paracellular transport of peptide drugs. At the same time, the drug can form a mixed micelle structure, and at higher concentrations, a multilayer micelle structure can be formed.
How safe is Salcaprozate Sodium?
SNAC has a generally recognized as safe (GRAS) status and is approved by the U.S. Food and Drug Administration (FDA) for use in pharmaceutical formulations (Eligen®-Vitamin B12, Emisphere, Roseland, NJ, USA), while sodium decanoate is available in the U.S. ( It has a long history of being approved as a food additive in both the US) and the European Union (EU), and is approved for use in drugs such as ampicillin rectal suppositories (Doktacillin®, Meda, Solna, Sweden). As a new type of pharmaceutical excipient, SNAC seems to have broad market prospects.
In vitro studies:
SNAC(12.5-400μg/mL;24h)hasnotoxicitytoCaco-2cells,andthesurvivalpercentageisabove90%whenSNACis200μg/mL.SNAC(50and200μgChemicalbook/mL)improvestheapparentpermeabilitycoeffcient(Papp)ofRAandSA-Bby2.14-foldand3.68-foldcomparedwiththePappofSAssolution .
In vivo studies:
SNAC improves theoralabsorption of both R1 and SA sandenhances bioavailability in rats. avagefor13weeks)inducesnomortalityintheWistarratstudyatdosesupto1000mg/kg/d.AnimalModel:Sprague- Dawleyrats(6-7weeks)Dosage:2000mg/kg/dAdministration:Oralgavagefor13weeksResult:Induced20%and50%mortalityinmalesandfemalesatthedoseof2000mg/kg/d.
Package and delivery

Delivery
1-80kg	80-300kg	More than 300kg
More suitable for express transportation, door-to-door	More suitable for air transportation,airport-to-airport	More suitable for ocean transportation,port-to-port
7-10 days for delivery time	3-4 days for delivery time	20-40 days for delivery time

What service we can provide
Joyous Health provides Salcaprozate Sodium powder OEM services. We can customize formulas for customers, private labels, capsules, tablets, soft capsules and sachets, low MOQ, which is suitable for direct sales by brands. Our OEM product shipping channels are stable and delivery times are fast and worthy of customers' trust, we have served more than 300 brands.

Joyous Health Factory information and certifications
Xi'an Joyous Health Biotechnology Co., Ltd. was established in 2011. Over the past 12 years, Joyous Health has obtained ISO 9001, FDA, ISO 22000, and GMP certifications.
Joyous Health has an advanced laboratory to control quality, so that each batch of products undergoes strict testing, and has professional R&D personnel to provide customized product services.
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Where to buy Salcaprozate Sodium powder?
We offer the best Salcaprozate Sodium powder at the most competitive price.Salcaprozate Sodium Powder bulk and wholesale powder have been 3rd lab-tested and verified for both product purity and identity.
We also provide Salcaprozate Sodium powder in bulk order or wholesale according to client needs. Just submit the requirements in the bottom form, we will reply soon!

Contacts: Faith Feng
Email:faith@joyouspellets.com
Tel and Whatsapp:+86 17391747738

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