Name: Punicalagin powder
Brand: Joyous Pellets Supplement raw materials, cosmetic ingredients, weight
Availability: InStock
Rating: 5 (1 reviews)

Pomegranate peel contains a large number of polyphenolic compounds, including ellagitannins, ellagic acid, gallic acid, catechins, etc. This is where our punicalagin comes from. Punicalagin is an oligomeric compound with 2 to 3 ellagic acids. It is the unique ellagitannin of pomegranate and the main component of the natural yellow pigment in pomegranate peel. A large number of studies have shown that punicalagin and ellagic acid have antibacterial, antioxidant, and anti-tumor effects.

Product Name

punicalagin

Specification

100:1

Appearance

Brown yellow powder

CAS No

65995-63-3

Molecular formula

C48H28O30

Packaging

25kg cardboard drum

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Desciption

Product information
What is Pomegranate peel extract punicalagin powder?
Punicalagin is the main component of pomegranate peel polyphenols and has various pharmacological effects such as antioxidant, anticancer, antibacterial, antiviral, and anti-inflammatory. After punicalagin is absorbed by the human body, it can be decomposed into ellagic acid under the action of human enzymes. It has excellent antioxidant properties and has been used as a food antioxidant. It is now mostly used in cosmetics in Japan and France. At the same time, ellagic acid has the effect of anti-mutagenicity and inhibiting the proliferation of cancer cells. It is often used to prevent and treat colon cancer, esophageal cancer, liver cancer, lung cancer, tongue and skin tumors and other diseases.
Joyous punicalagin powder specification

Terms	Standard	Terms	Standard
Product Name	punicalagin	Appearance	Brown powder
Assay	10%,20%,100:1	Loss on Drying	≤2%
Total Heavy Metals	≤10 ppm	Ash	≤2%
As	≤0.5ppm	Total Plate Count	≤750 cfu/g
Pb	≤0.5ppm	Yeast and Mold	≤100 cfu/g
Cd	≤0.5ppm	Coliforms	Negative
Hg	≤0.1ppm	E.Coli	Negative
Packing	Pack in 25kgs paper-drums, inner by double plastic bag	Shelf life	24 months under the above condition, and in its original package

Overview of Pomegranate Peel Extract?
Punicalagin is a polyphenol extracted from the leaves of pomegranate (Punica granatum L.) or Terminalia catappa L. It is an anti-hepatitis B virus (HBV) drug with antioxidant, anti-inflammatory and anti-cancer effects. It also has an effect on women's health. It also has the effect of preventing or slowing down vascular endothelial dysfunction, thereby reducing the risk of diseases such as arteriosclerosis and stroke. It also has a significant effect on common diseases in the digestive system, intestinal inflammation, etc.

Punicalagin has many properties that are beneficial to women’s health. 1. Antibacterial and anti-inflammatory: Punicalagin has significant antibacterial and anti-inflammatory effects, and can effectively resist gynecological inflammatory bacteria such as Candida and Escherichia coli. It has a significant effect on relieving itching, pain and other inflammatory symptoms. 2. Antioxidant: Punicalagin has powerful antioxidant properties, which can scavenge free radicals in the body, delay the aging process, and maintain skin firmness and elasticity. 3. Antiviral: Punicalagin has an inhibitory effect on various viruses such as influenza virus and herpes virus, and helps relieve gynecological diseases caused by viral infections. 4. Enhance immunity: Punicalagin can regulate the immune system, enhance resistance, help the body fight against various pathogens, and build a solid line of defense for the health of women's private parts. 5. Anti-tumor: Research shows that punicalagin has anti-tumor activity and can prevent the occurrence of certain gynecological tumors. Xiliren Antibacterial Antibacterial Gel for Women uses punicalagin and other key ingredients to provide women with private parts health protection, while also maintaining overall physical and mental health. Its natural, safe and effective properties make it an ideal choice for modern women.
Bacterial enteritis is a common disease of the digestive system. It is an acute intestinal inflammation caused by bacterial infection such as Staphylococcus aureus and Escherichia coli. It mainly manifests symptoms such as vomiting, fever, abdominal pain and diarrhea. This disease occurs in all types of people. , but the incidence rate is highest among children. Prolonged treatment without cure can lead to nutritional imbalance in children, which can seriously threaten the life and health of children. Punicalagin can reduce the incidence of intestinal cancer, diarrhea and gastric diseases by regulating intestinal flora. Studies have shown that punicalagin can significantly affect the cell wall integrity and cell membrane permeability of Staphylococcus aureus, and has a certain inhibitory effect on bacterial proteins; punicalagin is effective in Aspergillus fumigatus keratitis in C57BL/6 mice It can reduce the number of fungi, inhibit the number of macrophages and the function of secreting inflammatory factors, thereby reducing the inflammation score of fungal keratitis and inhibiting the expression of inflammation-related factors. These studies confirmed that punicalagin is selectively toxic to pathogenic bacteria, thereby modulating microbial imbalance. However, whether punicalagin can modulate intestinal flora through selective toxicity to pathogenic bacteria, thereby alleviating bacterial enteritis.

There are mouse experiments in which mice with enteritis induced by pathogenic Escherichia coli were treated with punicalagin to explore the effect of punicalagin on bacterial enteritis and its impact on intestinal flora.
Effect of punicalagin on body weight change rate of mice with bacterial enteritis
Diarrhea symptoms appeared about 12 hours after mice were inoculated with pathogenic Escherichia coli O101 suspension. The mice were mentally tired, had reduced food intake, had dull hair, yellow and loose stools, and secretions flowing out. Compared with the control group, the mice in the model group had less food, decreased activity ability, dull coat color, and decreased body weight. On the 4th day of self-administration, the decrease in body weight was statistically significant compared with the control group. Compared with the model group, the decrease in body weight on the 4th day of self-administration was statistically significant. On day 5, the body weight of mice in each administration group increased significantly.
Effect of punicalagin on DAI scores in mice with bacterial enteritis
The DAI scores of mice in each group were measured at a fixed time every day from the beginning of modeling. Compared with the control group, the DAI scores of the mice in the model group increased significantly from the 2nd day onwards; compared with the model group, the DAI scores of each drug administration group significantly reduced.
Effects of Punicalagin on MPO Activity in the Intestinal Wall of Mice with Bacterial Enteritis
MPO is an important indicator for evaluating the degree of neutrophil infiltration in tissues and can effectively reflect inflammatory conditions. Compared with the control group, the MPO activity in the intestinal wall of mice in the model group was significantly increased; compared with the model group, the MPO activity in the intestinal wall of mice in each administration group was significantly reduced.
Effects of punicalagin on the mRNA expression of inflammatory factors in the intestinal wall of mice with bacterial enteritis
Compared with the control group, the expression levels of NOD2, NF-κB p65, TNF-α and IL-6 mRNA in the intestinal wall of mice in the model group were significantly increased; compared with the model group, the intestinal wall NOD2, NF- The expression levels of κB p65, TNF-α and IL-6 mRNA were significantly reduced.
Effects of punicalagin on serum LPS, IL-6 and TNF-α levels in mice with bacterial enteritis
Compared with the control group, the levels of LPS, IL-6 and TNF-α in the serum of mice in the model group were significantly increased; compared with the model group, the levels of LPS, IL-6 and TNF-α in the serum of mice in each administration group were significantly higher. decrease.
Effects of punicalagin on the intestinal wall barrier of the small intestine in mice with bacterial enteritis
The intestinal mucosal structure of the mice in the control group was intact without ulcers, the villi in the small intestine were arranged tightly and regularly, and the epithelial cells had normal morphology; compared with the control group, the intestinal walls of the mice in the model group had obvious ulcers, the villi were sparse in density, disordered in arrangement, and had varying degrees of Shedding; the intestinal glands and epithelium of the mucosal layer were completely lost, accompanied by a large number of inflammatory cell infiltration, and the inflammation invaded the submucosa and muscle layer; the epithelial cells of the intestinal wall of mice in each administration group were shed less, the villi were more neatly arranged, and the inflammation Sex cell infiltration was reduced, and infection symptoms were significantly alleviated.
Effect of punicalagin on intestinal flora in mice with bacterial enteritis
Effect on the diversity of mouse intestinal flora A total of 5813 OTUs were obtained from 4 samples. The results showed that 358 OTUs were shared by 4 groups, of which 571 OTUs were shared between the control group and the model group, 632 OTUs were shared between the model group and punicalagin group, and 667 OTUs were shared between the model group and cefixime group. OTUs, Shannon index results showed that compared with the control group, the intestinal bacterial diversity of mice in the model group was significantly reduced; compared with the model group, the intestinal bacterial diversity of mice in each drug administration group was significantly increased. The results showed that, There were significant differences in the intestinal flora structure among the 4 groups.
In summary, punicalagin can improve bacterial enteritis induced by pathogenic Escherichia coli O101, reduce the inflammatory response of the intestinal wall of mice, and protect the intestinal wall barrier. Its mechanism may be related to the regulation of intestinal flora.

Package and delivery

Delivery
1-80kg	80-300kg	More than 300kg
More suitable for express transportation, door-to-door	More suitable for air transportation,airport-to-airport	More suitable for ocean transportation,port-to-port
7-10 days for delivery time	3-4 days for delivery time	20-40 days for delivery time

What service we can provide
Joyous Health provides punicalagin powder OEM services. We can customize formulas for customers, private labels, capsules, tablets, soft capsules and sachets, low MOQ, which is suitable for direct sales by brands. Our OEM product shipping channels are stable and delivery times are fast and worthy of customers' trust, we have served more than 300 brands.

Joyous Health Factory information and certifications
Xi'an Joyous Health Biotechnology Co., Ltd. was established in 2011. Over the past 12 years, Joyous Health has obtained ISO 9001, FDA, ISO 22000, and GMP certifications.
Joyous Health has an advanced laboratory to control quality, so that each batch of products undergoes strict testing, and has professional R&D personnel to provide customized product services.
For more details please click here

Where to buy punicalagin powder?
We offer the best punicalagin powder at the most competitive price. punicalagin Powder bulk and wholesale powder have been 3rd lab-tested and verified for both product purity and identity.
We also provide punicalagin powder in bulk order or wholesale according to client needs. Just submit the requirements in the bottom form, we will reply soon!

Contacts: Faith Feng
Email:faith@joyouspellets.com
Tel and Whatsapp:+86 17391747738

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Contact: Xi'an international enterprise center B building, Fengcheng 4 road, Xi'an City, Shaanxi province, China; info@joyouspellets.com; +86 17391747738

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